Exploring mesoporous silica nanoparticles as oral insulin carriers: In-silico and In vivo evaluation

The advancements in nanoscience have brought attention to the potential of utilizing nanoparticles as carriers for oral insulin administration. This study aims investigate effectiveness synthesized polymeric mesoporous silica (MSN) and their interactions with IR through in-silico docking. Diabetic rats were treated various MSN samples, including pure MSN, Amin-grafted MSN/PEG/Insulin (AMPI), Al-grafted (AlMPI), Zinc-grafted (ZNPI), Co-grafted (CMPI). nanocomposites using a hybrid organic-inorganic method involving MSNs, graphene oxide, insulin. Characterization was conducted X-ray diffraction (XRD), Fourier-transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM). In vivo tests included examination blood glucose levels histopathological parameters liver pancreas type 1 diabetic rats. family demonstrated significant reduction compared control group (p < 0.001). exhibited safety, non-toxicity, fast operation, self-repairing pancreas, cost-effectiveness, high efficiency delivery system. study, Zn-grafted selected. Docking results revealed strong between compounds IR, characterized by formation hydrogen bonds binding energy. Notably, showed highest docking scores −308.171 kcal/mol −337.608 respectively. These findings demonstrate effective insulin, offering promising prospects diabetes treatment.